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Abstract #2685

Amide Proton Transfer Imaging in Pancreatic Ductal Adenocarcinoma and Pancreatic Parenchyma

Akihiko Kanki1, Yoshihiko Fukukura1, Yuuki Sato1, Yu Ueda2, Takashi Iwanaga3, Akira Yamamoto1, and Tsutomu Tamada1
1Radiology, Kawasaki Medical School, Kurashiki, Japan, 2Philips Japan, minato-ku, Japan, 3Kagoshima University Hospital, Kagoshima, Japan

Synopsis

Keywords: Pancreas, Pancreas, Chemical exchange saturation transfer

Motivation: It is not known whether APT imaging is useful for the pancreas. In addition, the pancreas can be affected by the presence of fat deposition.

Goal(s): To verify whether APT-Dixon can be used for the pancreas, and to verify the differences between APT-TSE and APT-Dixon sequences.

Approach: APT-TSE and APT-Dixon sequences were compared for PDAC and the pancreatic parenchyma. APT signals within PDAC and pancreatic parenchyma were compared between APT-TSE and APT-Dixon sequences.

Results: APT-Dixon showed a significantly higher signal compared to APT-TSE in PDAC and the pancreatic parenchyma. PDAC showed a lower APT signal compared to the pancreatic parenchyma with APT-Dixon.

Impact: Pancreatic APT signal in APT-TSE is affected by the presence of fat deposition. Therefore, APT-Dixon is essential for analysis of the pancreatic APT signal. APT imaging in the pancreas may have the potential to assess the biological behaviour of PDAC.

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