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Abstract #2690

Leveraging Zero Echo Time (ZTE) MRI and ADC for Radiomics-Based Differentiation of Benign and Malignant Pulmonary Lesions

Jie Li1,2, Yi Xia1, Meiling Xu1, Xiaoqing Lin1, Song Jiang1, Jie Shi3, and Li Fan1
1Second Affiliated Hospital of Naval Medical University, Shanghai, China, 2College of Health Sciences and Engineering, University of Shanghai for Science and Technology, Shanghai, China, 3GE HealthCare, Shanghai, China

Synopsis

Keywords: Lung, Lung, Zero time echo; Apparent diffusion coefficient; Pulmonary cancer; Radiomics

Motivation: The unique advantages of ZTE for lung imaging remain underutilized in radiomics for pulmonary lesion differentiation. There is also a lack of studies integrating ZTE and ADC to distinguish between benign and malignant pulmonary lesions, presenting an opportunity to develop a more effective diagnostic model.

Goal(s): Develop and validate a radiomics model integrating ZTE and ADC to enhance the differentiation of benign and malignant pulmonary lesions.

Approach: 97 patients were enrolled. Radiomics features extracted from ZTE and ADC were analyzed.

Results: Among all radiomics models, the combination of ZTE and ADC demonstrated the highest diagnostic performance (AUC = 0.90).

Impact: By integrating ZTE and ADC in a radiomics model, the proposed approach has the potential to significantly improve the accuracy of pulmonary lesion differentiation

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