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Abstract #2692

The value of combined application of 3D-ASL and DWI imaging in the differential diagnosis of renal cell carcinoma and renal pelvic carcinoma

Shuang Qin1, Huarong Luo2, Yi Hong1, Saifei Sun1, Yaohua Liu1, Caixia Fu3, Bernd Kuehn4, and Qi Lv1
1Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai 200065, China, 2Department of Urology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai 200065, China, 3MR Application development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 4MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany

Synopsis

Keywords: fMRI Analysis, Kidney

Motivation: Given that renal cell carcinoma (RCC) and renal pelvis carcinoma (RPC) with parenchymal involvement present overlapping imaging features, their accurate differentiation is essential for guiding surgical approaches.

Goal(s): This study evaluates the diagnostic potential of three-dimensional arterial spin labeling (3D-ASL) and diffusion-weighted imaging (DWI) in differentiating RCC from RPC with renal parenchymal invasion.

Approach: This prospective study included 16 renal tumors patients and evaluated the differences in apparent diffusion coefficient (ADC) values and renal blood flow (RBF) ratio between RCC and RPC.

Results: Findings indicate that RCC has a significantly higher RBF ratio and lower ADC values. Combined use may improve diagnostic accuracy.

Impact: 3D-ASL, especially when combined with DWI, represents a promising, non-invasive approach for differentiating RCC from RPC. This contrast-free approach not only enhances patient safety but also expands diagnostic options for a broader patient population, supporting more flexible clinical decision-making.

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