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Abstract #2693

T2* Mapping to Characterize the Hypoxia - Microenvironment of Pancreatic Ductal Adenocarcinoma

Qi Jiang1, Jinggang Zhang1, Fuyao Liu1, Jie Chen1, Ya Lan2, Mingming Yang1, Derui Hu1, Jing Zhang3, and Siyuan Ouyang1
1The Third Affiliated Hospital of Soochow University, Changzhou, China, 2Changzhou Medical Center,Nanjing Medical University, Changzhou, China, 3MR Research Collaboration Team, Siemens Healthineers Ltd. Shanghai, China, Shanghai, China

Synopsis

Keywords: Pancreas, Pancreas, relaxometry;

Motivation: The study explores the correlation between T2* mapping values and pathological features in pancreatic ductal adenocarcinoma (PDAC), specifically examining the relationship with Hypoxia-inducible factor-1α (HIF-1α) expression.

Goal(s): To assess the validity of T2* values as a quantitative metric for evaluating hypoxia severity in PDAC.

Approach: T2* mapping was used to quantify the hypoxic microenvironment in PDAC, correlating T2* values with HIF-1α expression and pathological characteristics.

Results: Significant differences in HIF-1α expression were observed across PDAC differentiation grades, with a negative correlation between T2* values and HIF-1α expression.

Impact: T2* mapping provides a non-invasive method for assessing hypoxia in PDAC, potentially aiding in the early identification of aggressive tumors and enabling more personalized treatment approaches.

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Keywords