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Abstract #2704

Identifying renal intra-voxel compartment based on the diffusion-relaxation profiles and their correlation to pathology

Wentao Hu1, Fang Liu1, Tianshu Yang1, Yongming Dai2, and Yan Zhou1
1Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2School of Biomedical Engineering, ShanghaiTech University, Shanghai, China

Synopsis

Keywords: Kidney, Diffusion Modeling

Motivation: Renal pathology is essential in the diagnosis and treatment procedure of chronic kidney disease, including lupus nephritis (LN). However, it relies on percutaneous biopsy, which is invasive.

Goal(s): To identify renal intra-voxel compartment fractions based on the diffusion-relaxation profiles and their correlation to LN activity and chronicity index.

Approach: Diffusion-relaxation correlated 2D spectrum imaging (DR-CSI) & a novel compartment segmentation strategy based on correlation between spectral intensity and pathologic indices.

Results: Four compartments were identified. Significant difference exists for the fractions between impaired and normal function groups.

Impact: This explorative study raised a new spectral segmentation strategy of DR-CSI based on post-hoc correlation to pathology, suggesting four compartments with specific diffusion and relaxation properties. The findings provide insights for further research on renal DR-CSI.

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