Abstract #2707

Effect of Pregnancy on MRI measures of Kidney and Liver Cyst Growth Rates in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Vahid Bazojoo¹, Grace Lo¹, Line Malha¹, Jon D Blumenfeld^1,2, James M Chevalier^1,2, Arman Sharbatdaran¹, Hreedi Dev¹, Syed I Raza¹, Zhongxiu Hu¹, Vahid Davoudi¹, Chenglin Zhu¹, Xinzi He¹, Yin Wang¹, Mina Chookhachizadeh Moghadam¹, Usama Sattar¹, and Martin R Prince¹

¹Weill Cornell Medicine, New York, NY, United States, ²The Rogosin Institute, New York, NY, United States

Synopsis

Keywords: Liver, Body

Motivation: There is limited knowledge about pregnancy effects on renal and hepatic cyst growth in ADPKD.

Goal(s): To assess if renal and hepatic cyst growth rate during pregnancy is greater among ADPKD patients as compared to a non-ADPKD control group.

Approach: We used MRI scans to measure and compare total kidney and liver volume and cyst growth rates during and during non-pregnancy in 16 ADPKD patients, including subgroup analysis based on IVF status.

Results: Pregnancy was associated with increased kidney growth rate and a trend of cysts growing faster. Liver increased trend of growth in pregnancy was similar to non-ADPKD controls.

Impact: Female ADPKD patient should consider the risk of increase kidney growth prior to pregnancy.

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