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Abstract #2715

Common Neural Patterns of Substance Use Disorder: A Seed-based Resting-State Functional Connectivity Meta-Analysis

Feifei Zhang1
1First Hospital of Shanxi Medical University, Tai Yuan, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity

Motivation: The changes in cortical-striatal-thalamic-cortical functional connectivity patterns may be a common neural mechanism in substance addicted patients.

Goal(s): The present study aim to identify common neural patterns in patients with substance use disorder.

Approach: The seed-based D-mapping toolkit was used to analyzed connectivity patterns in key brain regions of the reward circuit, including the anterior cingulate cortex, prefrontal cortex, striatum, thalamus, and amygdala.

Results: The present study identifies disruptions in two critical reward circuits: the cortical-striatal-thalamic-cortical circuit and the cortical-striatal-hippocampus/parahippocampal gyrus-amygdala-cortical circuit.

Impact: All substance use disorder individuals have the same neural mechanism, which is the disruption of reward circuits.

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