Keywords: Functional Connectivity, Brain Connectivity
Motivation: The changes in cortical-striatal-thalamic-cortical functional connectivity patterns may be a common neural mechanism in substance addicted patients.
Goal(s): The present study aim to identify common neural patterns in patients with substance use disorder.
Approach: The seed-based D-mapping toolkit was used to analyzed connectivity patterns in key brain regions of the reward circuit, including the anterior cingulate cortex, prefrontal cortex, striatum, thalamus, and amygdala.
Results: The present study identifies disruptions in two critical reward circuits: the cortical-striatal-thalamic-cortical circuit and the cortical-striatal-hippocampus/parahippocampal gyrus-amygdala-cortical circuit.
Impact: All substance use disorder individuals have the same neural mechanism, which is the disruption of reward circuits.
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