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Abstract #2719

Relationship between perivascular space markers and cognitive impairment in subacute ischemic stroke

Yue Qin1, Xin Li1, Lei Wang1, Yifan Qian1, Yanqiang Qiao1, Wei Sheng2, and Shaoyu Wang2
1Department of Radiology, Xi'an Daxing Hospital, Xi'an, China, 2MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: fMRI Analysis, Stroke, Ischemic stroke

Motivation: The relationship between perivascular space markers and cognitive impairment in the subacute phase of IS remains unclear.

Goal(s): Our study aims to explore the relationship between PVS, DTI-ALPS and cognitive impairment in patients with subacute ischemic stroke.

Approach: We performed linear regression models to assess the correlation between these two magnetic resonance imaging metrics and to examine their relationship with cerebrovascular risk factors and cognitive impairment.

Results: This study found positive correlations between PVS burden, DTI-ALPS index and cognitive impairment in subacute ischemic stroke patients.

Impact: Our findings suggest that PVS burden and DTI-ALPS index may contribute to the pathophysiology of post-stroke cognitive impairment. This knowledge may ultimately inform the development of targeted interventions and therapeutic strategies aimed at preserving cognitive function in this population.

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