Meeting Banner
Abstract #2720

Pre-Stimulation Resting-State Connectivity at Dentate Nucleus Stimulation Contacts is Associated with Subsequent Motor Recovery Post-Stroke

Jacqueline Chen1, Ajay Nemani1, Xuemei Huang1, Stephen E Jones1, Mark J Lowe1, Kenneth B Baker1, and Andre M Machado1
1Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Data Processing, Functional Connectivity, Brain

Motivation: Dentate nucleus (DN) deep brain stimulation (DBS) can enhance motor recovery in chronic post-stroke participants, however current procedures for choosing contacts to activate requires time-consuming task-based evaluations.

Goal(s): To determine if pre-stimulation resting-state functional MRI (rsfMRI) connectivity of the brain at active contacts is associated with subsequent motor recovery.

Approach: Using each active contact location as a seed, z-maps were calculated from the pre-stimulation rsfMRI. If significant clusters were found in cortex, the contact was classified as FCcortical, otherwise it was classified as FCnon-cortical.

Results: The median motor recovery associated with active FCcortical contacts was significantly higher by 2.5-fold compared to FCnon-cortical contacts.

Impact: Our results show that pre-stimulation rsfMRI connectivity of the brain at active contacts is associated with subsequent motor recovery, supporting its use to streamline the identification of optimal contacts to activate for DN-DBS therapy to enhance post-stroke motor recovery.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords