Meeting Banner
Abstract #2724

Periaqueductal Gray Functional Connectivity Abnormalities Associated with Acute Post-Traumatic Headache

Simona Nikolova1, Catherine Chong1, Jing Li2, Wu Theresa3, Gina Dumkrieger1, Dmitry Esterov4, Katherine Ross5, Amaal Starling1, Aaron Thomas6, Michael Leonard1, Dani Smith1, and Todd Schwedt1
1Neurology, Mayo Clinic, Phoenix, AZ, United States, 2Georgia Tech, School of Industrial and Systems Engineering, Georgia, GA, United States, 3School of Computing and Augmented Intelligence Arizona State University, Tempe, AZ, United States, 4Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, United States, 5Phoenix VA Health Care System, Phoenix, AZ, United States, 6Emergency Medicine, Mayo Clinic, Phoenix, AZ, United States

Synopsis

Keywords: Functional Connectivity, Functional Connectivity, Periacqueductal Gray, FMRI, connectivity, migraine

Motivation: Studying periaqueductal gray (PAG) functional connectivity (FC) and headache improvement in participants with post traumatic headache (PTH) could provide insights into PTH pathophysiology.

Goal(s): Investigate PAG FC and headache improvement in participants with PTH due to mild traumatic brain injury (mTBI) compared to healthy controls (HC).

Approach: Examined resting state FC differences in PTH participants vs HCs.

Results: We observed stronger PAG FC to somatosensory, motor and occipital areas in PTH participants relative to HCs. Participants without headache improvement exhibited stronger FC from the PAG to right temporal and left insula regions relative to the improved group or HCs.

Impact: Altered PAG FC could be predictive of PTH outcome at 3 months. The high specificity of the model for predicting PTH improvement implies that persistent PTH could be detectable before it develops, allowing timely treatment and pain management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords