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Abstract #2747

Ultra-fast whole-brain 3D-EPI across scales: pushing high-performance gradients at 7T

Rüdiger Stirnberg1, Hendrik Mattern2, Oliver Speck2, and Tony Stöcker1,3
1MR Physics, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany, 3Department of Physics and Astronomy, University of Bonn, Bonn, Germany

Synopsis

Keywords: Pulse Sequence Design, High-Field MRI, High-performance gradients

Motivation: To push high-performance head gradients at 7T for two extreme ends of the spatiotemporal spectrum, namely ultra-fast and ultra-high-resolution whole-brain imaging.

Goal(s): To explore exceptionally fast gradient switching times and amplitudes for most efficient imaging using highly-accelerated segmented 3D-EPI.

Approach: Whole-brain time series with frame rates up to 90ms per volume (3mm isotropic resolution) and anatomical T2*-weighted images with 350 microns isotropic voxels (within 3.5 minutes) were acquired and used for venography, SWI and quantitative imaging.

Results: 1.) Fast and tSNR-efficient time series acquisitions and 2.) ultra-high-resolution whole-brain anatomical images and quantitative maps are demonstrated.

Impact: Utilizing highly-accelerated segmented 3D-EPI with high-performance head gradients at 7T, ultra-fast whole-brain fMRI protocols (up to 90ms per volume at 3mm isotropic) and ultra-high-resolution whole-brain anatomical/quantitative imaging with negligible motion blur (350 microns isotropic within 3.5 minutes) become possible.

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Keywords