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Abstract #2752

Effect of Gradient Impulse Response Function-based corrections on High-resolution FID Rosette Spectroscopic Imaging at 7T

Andres Saucedo1, Chenyang Zhao1, Steve Mendoza1, Ioannis Pappas1, and Danny JJ Wang1
1Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Image Reconstruction, Spectroscopy, Spectroscopic Imaging

Motivation: To assess the effect of applying k-space corrections for high-resolution (2mm in-plane) two-dimensional rosette FID MRSI using the measured gradient impulse response functions (GIRF).

Goal(s): To determine how applying GIRF-predicted k-spaces for all time points can improve the image reconstruction and quantitation accuracy of high-resolution MRSI, in which increased gradient performance is necessary.

Approach: GIRF-corrected and uncorrected metabolite maps, metabolite-to-Cr ratios, and estimates of the Cramer-Rao lower bounds (CRLBs) were compared for phantom and in vivo acquisitions.

Results: In vivo and phantom metabolite maps from GIRF-corrected reconstructions show a reduction in artifacts and fewer regions where the metabolite quantitation exceeded a 30% CRLB.

Impact: GIRF-based corrections for high-resolution FID MRSI have scarcely been shown in the literature. Accounting for gradient imperfections using the GIRF is crucial for non-Cartesian MRSI, particularly for high field and high-resolution acquisitions that demand high gradient performance.

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