Keywords: Pulse Sequence Design, CEST & MT
Motivation: To perform rapid, quantitative and volumetric CEST mapping.
Goal(s): To develop a multi-slice quantitative CEST pulse sequence and deep reconstruction approach for whole-brain mapping.
Approach: The schedule of flip angles and the temporal ordering of slices were optimized to minimize T1 relaxation effects. A neural network to quantify CEST parameters was trained based on temporal signals derived from simulations of the proposed pulse sequence.
Results: Water T1 and T2 maps, amide exchange and volume fraction maps, and semi-solid exchange and volume fraction maps were obtained in 10 slices with a scan time of ~2 minutes.
Impact: The proposed Q-MAJOR-CEST technique enables accurate and reproducible whole-brain quantitative CEST imaging in clinically relevant scan times that can be used for improved diagnosis and treatment response monitoring of brain tumors.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords