Meeting Banner
Abstract #2761

Quantitative Multi-slice And Jointly Optimized Rapid CEST (Q-MAJOR-CEST) for In Vivo Whole-Brain Imaging

Ouri Cohen1, Robert J. Young2, and Ricardo Otazo1,2
1Medical Physics, Memorial Sloan Kettering, New York, NY, United States, 2Radiology, Memorial Sloan Kettering, New York, NY, United States

Synopsis

Keywords: Pulse Sequence Design, CEST & MT

Motivation: To perform rapid, quantitative and volumetric CEST mapping.

Goal(s): To develop a multi-slice quantitative CEST pulse sequence and deep reconstruction approach for whole-brain mapping.

Approach: The schedule of flip angles and the temporal ordering of slices were optimized to minimize T1 relaxation effects. A neural network to quantify CEST parameters was trained based on temporal signals derived from simulations of the proposed pulse sequence.

Results: Water T1 and T2 maps, amide exchange and volume fraction maps, and semi-solid exchange and volume fraction maps were obtained in 10 slices with a scan time of ~2 minutes.

Impact: The proposed Q-MAJOR-CEST technique enables accurate and reproducible whole-brain quantitative CEST imaging in clinically relevant scan times that can be used for improved diagnosis and treatment response monitoring of brain tumors.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords