Abstract #2794

Multiparametric MRI Study Changes of Obese Patients with Type 2 Diabetes or Prediabetes Undergoing Bariatric Surgery.

Abi Spicer¹, Rebekah Wilmington^2,3, Chris Bradley^1,4, Martin Craig¹, Stephen LLoyd-Brown⁵, Elizabeth J Simpson^4,6, Stephen Bawden^1,4, Guruprasad Aithal^4,7, Penny Anne Gowland^1,4, Iskandar Idris^2,8, and Susan T Francis^1,4

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ³Bariatric Metabolic Institute, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom, ⁴NIHR Nottingham Biomedical Research Centre, Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom, ⁵Intelligent Modelling and Analysis, School of Computer Science, University of Nottingham, Nottingham, United Kingdom, ⁶David Greenfield Human Physiology Unit, MRC/ARUK Centre for Musculoskeletal Ageing Research,, University of Nottingham, Nottingham, United Kingdom, ⁷Nottingham Digestive Diseases Centre, Translational Medical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom, ⁸Bariatric Metabolic Institute, University Hospitals of Derby and Burton NHS foundation Trust, Derby, United Kingdom

Synopsis

Keywords: Liver, Diabetes, Bariatric, Pre-Diabetes, Liver, Pancreas, Spleen, NAFLD, MASLD

Motivation: Bariatric surgery induces weight loss and Type 2 diabetes remission, but the mechanism/changes across insulin sensitive organs are unclear.

Goal(s): To quantify changes in liver, spleen, pancreas and Subcutaneous Adipose Tissue (SAT).

Approach: Multiparametric MRI of fat fraction (FF), T₂* and volume, T₁ and T₂, B₁ and B₀ at four timepoints before and after bariatric surgery.

Results: A significant reduction was seen in liver and spleen volume, liver T₁, and liver and spleen FF and SAT which correlated with reduced Body Mass Index (BMI)/Body Surface Area (BSA). BSA negatively correlated with liver B₁ leading to an overestimation in measured liver T₂.

Impact: MRI is used to assess changes in liver, spleen and pancreas volume, fat, relaxometry (T₁, T₂* and T₂) and subcutaneous fat before and after bariatric surgery. These measures serve as markers for longitudinal and cross-sectional assessment of response to surgery.

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