Abstract #2805

Novel algorithm for quantification of pancreatic exocrine function from Secretin-MRCP is concordant with endoscopic findings

Alexander R. Guimaraes¹, Aaron Streblow², Kaveh Sharzehi³, Bryan Foster³, Gregory Cote³, and Cory Wyatt¹

¹Radiology, OHSU, Portland, OR, United States, ²Medicine, OHSU, Portland, OR, United States, ³OHSU, Portland, OR, United States

Synopsis

Keywords: Pancreas, Pancreas, MRCP with secretin

Motivation: To improve MRCP with Secretin variability in determining exocrine pancreatic function (ePFT).

Goal(s): To develop and assess a model for assessing ePFT based on MRCP with secretin modulation

Approach: A retrospective study evaluating our new model compared to serum fecal elastase (FE) or ePFT. A reader-study was performed to assess radiologist variability.

Results: 1) There was moderate agreement between radiologists in our reader study. 2) There was no correlation in any model derived variable and FE or between FE and ePFT. 4) There was a statistically significant difference in kappa delay derived from our model and ePFT.

Impact: This novel paradigm may be a more effective comparator for ePFT in patients

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