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Abstract #2809

NMR-Based Targeted Metabolic Profiling for Discovery of Urinary Biomarkers in Male Lower Urinary Tract Symptoms

Pradeep Kumar1, Virendra Kumar1, Rajeev Kumar2, Sanjay Sharma3, Sanjay Thulkar4, and Maroof Ahmad Khan5
1NMR, All India Institute Of Medical Sciences, New Delhi, India, 2Urology, All India Institute Of Medical Sciences, New Delhi, India, 3Radiadiagnosis,RPC, All India Institute Of Medical Sciences, New Delhi, India, 4Radiology , IRCH, All India Institute Of Medical Sciences, New Delhi, India, 5Biostatistics, All India Institute Of Medical Sciences, New Delhi, India

Synopsis

Keywords: Urogenital, biomarkers, Metabolomics,NMR and urine

Motivation: Lower Urinary Tract Symptoms (LUTS) in males are prevalent and often associated with conditions like benign prostatic hyperplasia, but current diagnostic methods are invasive and lack specificity.

Goal(s): The goal of this study is to identify novel urinary biomarkers that could serve as non-invasive diagnostic tools for male LUTS.

Approach: Metabolomics study of urine demonstrated a potential for discrimination between LUTS and HC using 1H-NMR and machine learning or AI tools.

Results: Dimethylamine, dimethylglycine, creatine, creatinine, tyrosine, histidine, indoxyl sulfate associated with inflammation, oxidative stress, and microbiota derived metabolites.

Impact: This study has the potential to significantly improve LUTS diagnosis by offering a non-invasive alternative to current methods.

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Keywords