Abstract #2819

Analysis of Magnetic Resonance Elastography Prostate Biomarkers in Healthy and Lower Urinary Tract Symptoms Subjects

Cody Johnson^1,2, Juan Pablo Gonzalez-Pereira^1,3, William A Ricke², Matthew D Grimes², Timothy J Hall⁴, Yun Jiang⁵, Vikas Gulani⁶, Alejandro Roldan-Alzate^1,3,7, Christopher L Brace¹, and Shane A Wells^6,8

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Urology, University of Wisconsin-Madison, Madison, WI, United States, ³Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Nursing, University of Michigan-Ann Arbor, Ann Arbor, MI, United States, ⁶Radiology, University of Michigan-Ann Arbor, Ann Arbor, MI, United States, ⁷Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁸Urology, University of Michigan-Ann Arbor, Ann Arbor, MI, United States

Synopsis

Keywords: Prostate, Elastography, Magnetic Resonance Elastography, Prostate, Benign Prostate Hyperplasia, Lower Urinary Tract Symptoms, Shear Stiffness

Motivation: There is a critical need for significant improvements in image-based assessment of the prostate in men with lower urinary tract symptoms (LUTS).

Goal(s): To characterize anatomical and histological changes of the prostate in subjects with LUTS, using mpMRI and transperineal magnetic resonance elastography (pMRE).

Approach: Quantify transition zone (TZ) complex shear modulus [henceforth ‘shear stiffness’ (SS)] with pMRE at 90Hz.

Results: Median SS of the periurethral TZ is highest in subjects with Moderate/Severe LUTS at 4.1kPa versus mild LUTS 3.5kPa (p=0.02) and no LUTS 3.4kPa (p=0.02). The periurethral region of the TZ had decreased stiffness compared to the rest of the TZ.

Impact: pMRE is a novel, noninvasive imaging technique that can show spatial heterogeneity of the prostate and increased prostate stiffness with increasing severity of LUTS, demonstrating its potential as a useful biomarker in identifying phenotypes of LUTS.

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