Abstract #2820

MRE-derived stiffness of the kidney in Chronic Kidney Disease: Association with estimated glomerular filtration rate and MR relaxation time

Chris R Bradley^1,2, Charlotte E Buchanan¹, Martin Craig^1,2, Maarten W Taal^3,4, Nicholas M Selby^3,4, Eleanor F Cox^1,2, and Susan T Francis^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom, ³Academic Unit for Translational Medical Sciences, Centre for Kidney Research and Innovation, Nottingham, United Kingdom, ⁴Department of Renal Medicine, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom

Synopsis

Keywords: Kidney, Kidney, Elastography, Relaxometry, chronic kidney disease

Motivation: Magnetic Resonance Elastography (MRE) has been shown to provide a measure of organ stiffness, but its application in chronic kidney disease (CKD) is poorly understood.

Goal(s): To evaluate whole kidney MRE stiffness and compare this to MR relaxometry measures of inflammation and fibrosis, and estimated glomerular filtration rate (eGFR) in CKD participants and healthy volunteers (HV).

Approach: Spin-echo EPI MRE-derived stiffness acquired using Resoundant hardware on patients with CKD and HV.

Results: Whole kidney MRE-derived stiffness was lower in CKD compared to HVs, and positively correlated with eGFR, despite an increase in renal T₁ and T₂ with lower eGFR reflecting increased inflammation/fibrosis.

Impact: MRE stiffness of the kidneys in conjunction with other MRI parameters may provide a more comprehensive assessment of the underlying structure, function and pathology as inflammation and fibrosis increase in patients with chronic kidney disease.

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