Abstract #2834

Single-Site Experience of Liver Fat and Iron Quantitation with a 2D Flip Angle Modulated CSE-MRI Sequence in the Clinical Setting

Eugene Milshteyn¹, Arnaud Guidon¹, Jiayi Tang^2,3, Scott B. Reeder^2,3,4,5,6, Diego Hernando^2,3, Nabih Nakrour⁷, Mukesh G. Harisinghani⁷, and Amirkasra Mojtahed⁷

¹GE HealthCare, Boston, MA, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Radiology, Massachusetts General Hospital, Boston, MA, United States

Synopsis

Keywords: Liver, Liver, Fat, Iron, CSE-MRI

Motivation: 2D Flip Angle Modulated (FAM) CSE-MRI is a novel, free-breathing fat and iron quantitation sequence that still needs to be validated in the clinical setting.

Goal(s): To compare the IQ and quantitative metrics of free-breathing 2D FAM CSE-MRI and breath-held 3D CSE-MRI in the clinical setting at a single site.

Approach: 79 patients were scanned with both 2D FAM and 3D CSE-MRI sequences. A trained radiologist assessed the IQ/apparent SNR/artifacts/PDFF/R2* values for each of the two sequences.

Results: 2D FAM CSE-MRI showed improved IQ, apparent SNR, and fewer artifacts compared to the 3D CSE-MRI, while showing no statistically significant difference in PDFF/R2* values.

Impact: With its free-breathing nature and reproducible PDFF and R2* values compared to gold standard 3D CSE-MRI, 2D FAM CSE-MRI shows promise as a routine tool in clinical liver fat and iron quantitation.

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