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Abstract #2839

Multiparametric 3D-MRE for Longitudinal Monitoring of Disease Progression in CHB Patients, With or Without Treatment

Yiyang Wang1, Zhiying Wang2, Ruobing Bai2, Haonan Guan3, and Yu Shi2
1Department of Radiology, Shengjing Hospital of China Medical University, Shenyang,Liaoning, China, 2Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China, 3GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Liver, Treatment Response

Motivation: Three-dimensional magnetic resonance elastography (3D-MRE) can detect necroinflammation and fibrosis in chronic hepatitis B (CHB) patients. However, few studies have examined the ability of 3D-MRE to monitor liver changes in CHB patients, both with and without antiviral treatment.

Goal(s): To develop a non-invasive follow-up method using 3D-MRE for both treated and untreated CHB patients.

Approach: Cohen’s Kappa test compared the agreement between disease progression diagnosed by pathology or clinical criteria and that diagnosed by MRE. Spearman correlation analysis was performed between changes in 3D-MRE and liver histology or clinical indicators during follow-up.

Results: 3D-MRE effectively monitors disease progression in CHB patients during follow-up.

Impact: 3D-MRE offers a non-invasive biomarker for longitudinal monitoring in CHB patients.

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