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Abstract #2867

Changes of pain matrix connectivity in painful diabetes peripheral neuropathy

Miao He1, Jiaying Yang1, Xueqing liu1, Jiamin Zhou1, Xuewei Zhang1, jing li1, Xiali shao1, wenhui li2, Yuzhou Guan3, weihong Zhang1, and feng Feng1
1Radiology, Beijing, China, 2Endocrinology, Beijing, China, 3Neurology, Beijing, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity

Motivation: Explore the possible pain mechanism related to function in patients with diabetes peripheral neuropathy

Goal(s): to explore changes in functional connectivity within key pain-related brain regions among patients with diabetic peripheral neuropathy.

Approach: Time courses from 17 pain-related brain regions were extracted and analyzed for ROI-to-ROI functional connectivity.

Results: Significant differences in FC were noted among the groups, particularly between the thalamus and periaqueductal gray (PAG), and the insula and medial prefrontal cortex (mPFC).

Impact: Understanding the pain mechanism related to function in patients with diabetes peripheral neuropathy (DPN) is of great significance for improving the prognosis of patients.

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