Keywords: Data Processing, Digestive, Crohn’s Disease; Fibrosis; 3D printing; MR enterography
Motivation: Due to spatial heterogeneity, accurate diagnosis of intestinal fibrosis is an unmet need for patients with Crohn’s disease (CD).
Goal(s): To investigate whether sub-regionalization improves diagnostic accuracy of MRE for CD fibrosis and develop optimal MRE models.
Approach: Longitudinal co-registration of MRE with pathology was achieved using 3D printing, while axial co-registration of MCFI on MRE and pathology. Optimal multivariable MRE models were constructed. The diagnostic ability was evaluated by AUC.
Results: After sub-regionalization, histological fibrosis scores were highest in mesenteric border region(all P<.05). The optimal models showed the highest diagnostic accuracy for mesenteric border (AUC=0.91).
Impact: In CD patients, there is a notable fibrosis heterogeneity in the gut. This heterogeneity is pivotal in affecting diagnostic accuracy of fibrosis. Consequently, it is imperative to adopt a sub-regional diagnostic approach to ensure precision in medical assessment and treatment.
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