Abstract #2885

Volumetric T1 and ADC Mapping Aids in Lung Nodule Detection: An MRI-Based Approach

Chaowei Wu^1,2, Krista Dollar³, Weijia Chua^3,4, Hsu-Lei Lee¹, Chang Gao⁵, Christopher Lee⁶, Patricia Thompson³, Debiao Li^1,2, Yibin Xie¹, and Sara Ghandehari³

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Division of Pulmonary & Critical Care Medicine, Stanford University, Stanford, CA, United States, ⁵MR R&D Collaborations, Siemens Medical Solutions USA, Inc, Los Angeles, CA, United States, ⁶Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Keywords: Lung, Lung, Pulmonary, UTE-MRI

Motivation: The National Lung Screening Trial (NLST) demonstrated that low-dose CT screening reduces lung-cancer-specific mortality but raises concerns about radiation exposure.

Goal(s): This study explores MRI as a non-ionizing alternative, for detecting and characterizing lung nodules in high-risk populations.

Approach: We used a 3D UTE sequence at 3T for high-resolution MRI and integrated T1 and ADC mapping to assess MRI’s potential to characterize nodules effectively.

Results: Significant T1 and ADC contrasts between nodules and surrounding parenchyma (P<0.001) were observed in patients with CT-confirmed lung nodules, suggesting that MRI could be a non-radiative alternative for lung nodule imaging, with T1 and ADC mapping enhancing detection.

Impact: MRI with T1 and ADC mapping shows promise as a radiation-free alternative for lung nodule detection, potentially improving screening safety and accuracy in high-risk individuals.

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