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Abstract #2892

Evaluating MRI Response in Breast Tumours Treated with Radiotherapy – Can Apparent Diffusion Co-efficient (ADC) Predict Long Term Response?

Emily Durie1,2, Megan Morris1,3, Seema Salehi4, Nuala Healy5, Archana Seth6, Nina Tunariu2, Steven Allen2, Miklos Barta7, Aditi Chandra8, C A Rakesh9, Philip Borg10, Shalini Sahu11, Purvi Haria12, Mengxing Tang3, Navita Somaiah1,2, and Matthew David Blackledge1
1Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, United Kingdom, 2The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 3Department of Bioengineering, Imperial College London, London, United Kingdom, 4University Hospitals of North Midlands, Stoke-on-Trent, United Kingdom, 5Royal College of Surgeons in Ireland, Dublin, Ireland, 6NHS Greater Glasgow and Clyde, Glasgow, United Kingdom, 7Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom, 8Tata Medical Centre, Kolkata, India, 9Regional Cancer Centre, Thiruvananthapuram, India, 10The Christie NHS Foundation Trust, Manchester, United Kingdom, 11Christian Medical College, Vellore, India, 12Tata Memorial Centre, Mumbai, India

Synopsis

Keywords: Treatment Response, Cancer

Motivation: Research on how primary breast tumours in situ respond to radiotherapy is very limited, though increasingly relevant as neo-adjuvant radiotherapy trials expand, requiring accurate and sensitive monitoring of therapy response.

Goal(s): To evaluate MRI response in breast tumours treated with radiotherapy and assess whether ADC values or their changes predict long-term outcomes.

Approach: Twenty-five patients underwent radiotherapy to in-situ breast tumours with the aim of long-term control. CE-DW-MRI was performed at baseline and 2W, 6M and 12M post-radiotherapy.

Results: Early ADC changes at 2-weeks post-radiotherapy correlated more strongly with long-term response than later ADC changes.

Impact: Early assessment of ADC on DW-MRI after radiotherapy treatment could predict long term responses in breast tumours. This could allow future personalisation of radiotherapy doses based on baseline ADC values of tumours.

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