Keywords: Deuterium, Metabolism, Cardiac DMI, clinical field
Motivation: A noninvasive MR imaging tool for detection of abnormal cardiac metabolism detection is needed for many cardiovascular diseases.
Goal(s): Our goal was to develop Deuterated Metabolic Imaging (DMI) on a clinical 3T MRI scanner for human myocardial metabolic mapping.
Approach: We investigated a multi-echo bSSFP based sequence and Hierarchical IDEAL reconstruction in simulations, and phantom and in vivo experiments, to isolate deuterated glucose and its products.
Results: DMI at 3T was able to distinguish water and glucose, and provided reasonable in vivo metabolic mapping after deuterated glucose injection.
Impact: The first study of human cardiac DMI at 3T was performed using multi-echo bSSFP, showing capability to isolate deuterated water and glucose in a 10min scan, and advantages over multi-echo GRE and conventional magnetic resonance spectroscopic imaging (MRSI).
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