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Abstract #2902

Metabolic Myocardial Mapping with Multi-echo bSSFP: Pilot study in humans on a clinical 3T MRI scanner

Jie Xiang1, Robin A. de Graaf2, Henk M. DeFeyter2, Monique A. Thomas2, Lauren A. Baldassarre3, Jennifer M. Kwan3, Albert J. Sinusas3, Edward J. Miller3, and Dana C. Peters2
1Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 2Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 3Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States

Synopsis

Keywords: Deuterium, Metabolism, Cardiac DMI, clinical field

Motivation: A noninvasive MR imaging tool for detection of abnormal cardiac metabolism detection is needed for many cardiovascular diseases.

Goal(s): Our goal was to develop Deuterated Metabolic Imaging (DMI) on a clinical 3T MRI scanner for human myocardial metabolic mapping.

Approach: We investigated a multi-echo bSSFP based sequence and Hierarchical IDEAL reconstruction in simulations, and phantom and in vivo experiments, to isolate deuterated glucose and its products.

Results: DMI at 3T was able to distinguish water and glucose, and provided reasonable in vivo metabolic mapping after deuterated glucose injection.

Impact: The first study of human cardiac DMI at 3T was performed using multi-echo bSSFP, showing capability to isolate deuterated water and glucose in a 10min scan, and advantages over multi-echo GRE and conventional magnetic resonance spectroscopic imaging (MRSI).

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Keywords