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Abstract #2907

Deuterium MRI for characterizations of glucose metabolism in subcutaneous bladder cancer models.

Bei Weng1, Ganghan Yang2, Lingmin Kong1, Zhihua Wen1, Yan Guo1, and Huanjun Wang1
1Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Synopsis

Keywords: Deuterium, Deuterium

Motivation: Bladder cancer is a common malignant tumor with a high recurrence rate. Metabolic imaging may be an effective method for accurate diagnosis, especially deuterium MRI, which overcomes the shortcoming of bladder tumor signals masked by urine in PET.

Goal(s): To characterize the metabolism of bladder cancer using deuterium MRI.

Approach: Mice model of subcutaneous bladder cancer was established for deuterium MRI.

Results: The “warburg effect” of bladder tumors can be visualized by deuterium MRI, as shown by increased 2H-glucose uptake and 2H-lactate and 2H-water production.

Impact: Our study established that deuterium MRI holds promise to depict the metabolism of bladder cancer. Deuterium MRI is a safe, non-radioactive, and effective imaging modality to diagnosis bladder cancer and guide clinical treatment in the future.

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