Keywords: Deuterium, Deuterium, Cerebral glucose consumption; Magnetic Resonance Spectroscopic Imaging; Kinetic Model; Metabolic rate
Motivation: Quantitative assessment of cerebral glucose metabolism and metabolic rates using deuterium MRS imaging (2H-MRSI) is still challenging.
Goal(s): To develop an advanced kinetic model and a robust fitting algorithm enabling the accurate determination of brain kinetic parameters and blood input function.
Approach: A kinetic model incorporating brain glucose transport, glucose consumption, aerobic glycolysis, and TCA cycle rates was developed and validated through animal studies at 16.4T.
Results: The proposed model and algorithm reliably and simultaneously estimated blood input functions and key kinetic parameters, including cerebral glucose consumption, aerobic glycolysis and TCA cycle rates.
Impact: Reliable and quantitative assessment of cerebral metabolic rates of glucose metabolism along non-oxidative and oxidative pathways is critical for studying brain energy metabolism and metabolic reprogramming. The proposed method has the potential for broad applications in various neurological diseases.
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