Keywords: Deuterium, Deuterium, Brain, metabolism
Motivation: Deuterium MRS imaging (DMRSI) enables mapping downstream metabolites of oxidative and non-oxidative glucose metabolism and is crucial for imaging brain tumors and neurodegenerative diseases.
Goal(s): To develop a high-resolution whole-brain DMRSI acquisition tool to assess brain deuterated metabolites and their dynamics.
Approach: We applied the 3D-checkerborad Grappa to acquire human whole-brain DMRSI at 7T after deuterated glucose ingestion with 2:50min scan time and 0.4cc nominal voxel size.
Results: After SPICE denoising, the 3D-checkerborad Grappa DMRSI provided high spatiotemporal-resolution metabolite concentration maps, showing excellent imaging contrasts of HDO, Glx and Glucose contents across GM, WM and CSF.
Impact: The proposed parallel DMRSI approach enables quantitative assessment of deuterated glucose metabolite concentrations and dynamics with higher spatiotemporal resolution throughout the human brain, making it possible to determine oxidative and non-oxidative glucose metabolic rates with improved resolution and tissue contrasts.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords