Meeting Banner
Abstract #2910

Quantitative Lymphatic Imaging Using Deuterated Particle Imaging

Lisa M. Fries1,2, Elton T. Montrazi3, Hyla Allouche-Arnon4, Felipe Opazo2,5, Amnon Bar-Shir4, Lucio Frydman3, and Stefan Glöggler1,2
1NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, 2Center for Biostructural Imaging of Neurodegeneration, University Medical Center, Göttingen, Germany, 3Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 4Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot, Israel, 5Institute for Neuro- and Sensory Physiology, University Medical Center, Göttingen, Germany

Synopsis

Keywords: Deuterium, Deuterium

Motivation: Imaging the lymphatic system remains challenging due to its complex structure and limited accessibility. Achieving non-invasive, quantitative imaging at sufficient depth is demanding with current techniques.

Goal(s): To assess whether deuterated nano-polymers could serve as minimally invasive tracers for quantitative mapping of inflammatory activity via high-field 2H MRI.

Approach: Deuterated PAMAM dendrimers were synthesized and mapped by 2H MRI at 15.2 T with a CSI-SSFP sequence on a rodent inflammation model.

Results: Deuterated Particle Imaging (DPI) targeting nano-polymers with 2H MRI can identify inflammation sites post systemic administration, through hotspot MRI mapping of lymphatic uptake.

Impact: This innovative technique enhances research in inflammation and immune response by providing quantitative insights into physiological processes. It could advance our understanding of lymph node activity in vivo through deuterium MRI combined with deuterated nano-polymers in an inflammatory rodent model.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords