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Abstract #2913

Dynamic mapping of Glc oxidative metabolism in rats with indirect 1H-FID-MRSI deuterium detection at 9.4T

Alessio Siviglia1,2, Brayan Alves1,2, Fabian Niess3, Zenon Starčuk Jr.4, Wolfgang Bogner3, Bernhard Strasser3, Cristina Cudalbu1,2, and Bernard Lanz1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Medical University of Vienna, Vienna, Austria, 4Institute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech Republic

Synopsis

Keywords: Deuterium, Metabolism, Deuterium, MRSI, FID-MRSI, Ultra-high field, Preclinical, Rat

Motivation: Deuterium metabolic imaging shows great potential to non-invasively map regional glucose oxidative metabolic fluxes in the brain. However, reaching sufficient spatial and temporal resolution in preclinical setups remains a challenge.

Goal(s): Achieve a satisfactory balance between SNR, spatial and temporal resolution to characterise glucose oxidative metabolism into glutamate+glutamine (Glx) turnover.

Approach: An optimised 1H-FID-MRSI protocol was used at 9.4T with a cryogenic receive RF probe to characterise 2H labelling through signal decay.

Results:
Dynamic 1H-FID-MRSI upon continuous infusion of 2H-labelled Glc enabled the reproducible measurement of regional Glx turnover curves in the rat brain.

Impact: Our work shows the potential of recently developed preclinical 1H-FID-MRSI protocols to track 2H labelling in downstream glucose metabolism in a quantitative way, with sufficient SNR to characterise the time course of glutamate-glutamine turnover with regional specificity.

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