Abstract #2914

Tissue Water Referencing with Proton Density in MRSI for Metabolic Mapping at 7T

Ahmet Azgin^1,2, Philipp Lazen^1,2, Barbara Dymerska³, Martina F. Callaghan³, Simon Robinson^2,4, Lukas Hingerl², Bernhard Strasser², Wolfgang Bogner^2,4, Karl Rössler^1,4, Siegfried Trattnig^2,4,5, and Gilbert Hangel^1,2,3

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Department of Biomedical Imaging and Image-guided Therapy, High-Field MR Center, Vienna, Austria, ³Department of Imaging Neuroscience, Functional Imaging Laboratory, London, United Kingdom, ⁴Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, ⁵Karl Landsteiner Society, Institute for Clinical Molecular MRI,, Vienna, Austria

Synopsis

Keywords: Spectroscopy, Quantitative Imaging, 7T, MRSI, Concentration Estimates, Tumor Imaging

Motivation: In MRSI, obtaining concentration estimates is desirable to using metabolite ratios. We were limited due to segmentation. PD-based water maps can address this issue.

Goal(s): To compare and validate metabolic imaging using PD-based approach, and compared against literature-driven strategy.

Approach: Quantitative proton density maps are used to arrive at the water content for metabolic imaging at 7T, allowing concentration estimation based on internal water mapping with PDs.

Results: A PD-based tissue referencing was successfully implemented and compared against a literature-driven approach in 13 volunteers and one tumor patient. Regional comparisons showed ~4% difference between, with values aligning with the previously established ranges

Impact: Using quantitative proton density maps as an internal reference for MRSI enables to get concentration estimates from not only healthy brains, but also in pathological ones like brains with glioma.

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