Abstract #2915

Double-DANTE-PRESS: a multi-metabolite-selective 1H-MRS sequence for human brain measurements of glutamate and glutathione at 7T

Kesavi Kanagasabai^1,2, Omer Oran^1,3, Lena Palaniyappan^1,4, and Jean Theberge^2,5

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Siemens Healthcare Limited, Oakville, ON, Canada, ⁴Douglas Mental Health University Institute, Montreal, QC, Canada, ⁵Lawson Research Institute (Lawson) at St. Joseph's Health Care London, London, ON, Canada

Synopsis

Keywords: Spectroscopy, Spectroscopy

Motivation: Spectral editing is commonly used in human brain 1H-MRS to isolate neurochemicals of interest however, spectral editing doubles scan time, is more prone to motion, and provides lower signal-to-noise ratios (SNR) efficiency.

Goal(s): Our goal is to develop and validate a single-shot metabolite-selective 1H-MRS sequence to isolate two selected neurochemicals of interest simultaneously at 7T to simplify spectral modelling.

Approach: We introduced/implemented double-DANTE-PRESS and assessed reproducibility within and between scans in phantoms and in vivo.

Results: We were able to isolate neurochemical of interest and suppress unwanted signals higher precision and SNR efficiency.

Impact: Double-DANTE-PRESS is a single-shot multi-metabolite-selective 1H-MRS sequence that can be used to access neurotransmission involving glutamate and glutathione with high precision and higher SNR efficiency while simplifying spectral modelling.

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