Abstract #2916

MR Spectroscopy using the Intraoperative MR System

Lorenz Pfleger^1,2, Ralph Flandorfer¹, Matthias Tomschik¹, Karl Rössler¹, Gregor Kasprian³, and Gilbert Hangel^1,2,4

¹Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Biomedical Imaging and Image-guided Therapy, High-Field MR Center, Medical University of Vienna, Vienna, Austria, ³Biomedical Imaging and Image-guided Therapy, Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Vienna, Austria, ⁴Biomedical Engineering, King's College London, School of Biomedical Engineering and Imaging Sciences, London, United Kingdom

Synopsis

Keywords: Spectroscopy, MR-Guided Interventions, intraoperative MR, spectroscopy, MR-guided, laser-induced thermal therapy, sLASER

Motivation: Intraoperative magnetic resonance spectroscopy (ioMRS) has rarely been applied, although it offers high potential. It could be introduced to MR-guided laser-induced thermal therapy (MRgLITT) for improving cancer treatment.

Goal(s): The aim was to compare two MRS sequences measured with a conventional and an intraoperative (io) coil at different brain regions.

Approach: 10 healthy subjects were measured at 3T with a conventional and an io coil using a PRESS and sLASER sequence in the cingulate gyrus and amygdala.

Results: Better spectral quality was gained with the conventional coil in regions closer to the coil. No differences in concentrations were found between the coils.

Impact: Intraoperative MR spectroscopy (ioMRS) is feasible and has been performed for the first time with an sLASER sequence. Future implementation in MR-guided laser-induced thermal therapy (MRgLITT) allows tracking of metabolic changes due to LITT.

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