Keywords: Spectroscopy, Neuro, Reproducibility, GABA, glutathione, hippocampus
Motivation: Quantification of measurement reproducibility of in vivo MRS experiments enables the planning of future studies. Evidence of reproducibility of simultaneous measurement of GABA and GSH using Hadamard-encoded spectral editing (i.e., HERMES) in challenging brain regions for MRS, such as the mesial temporal lobe (MTL), is needed.
Goal(s): Determine the reproducibility of HERMES-sLASER in the MTL.
Approach: Two MTL HERMES scans were acquired in 15 participants, with participants repositioned between scans.
Results: The average CV for GABA+ was 14.09% and the average CV for GSH was 18.94%, comparable to previous work investigating these metabolites in the MTL using standalone acquisitions.
Impact: This study quantifies the reproducibility of HERMES-sLASER in the challenging region of the mesial temporal lobe. These results show that this technique can be used to measure multiple metabolites by editing them simultaneously and provides guidance on expected effect sizes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords