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Abstract #2920

Feasibility of in vivo metabolic profiling in the human brainstem periaqueductal gray matter by 1H-MRS at 7T

Pandichelvam Veeraiah1,2, Sanne Schins1, Kim Brouwers1,2, Jack van Asten3,4, Job van den Hurk1,5, Joachim E Wildberger2,6, Tom W.J Scheenen3,4, and Jeanine J Prompers1,2,7
1Scannexus (Ultra-high field MRI center), Maastricht, Netherlands, 2Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands, 3Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany, 4Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands, 5Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 6Cardiovascular Research Institute Maastricht, (CARIM), Maastricht University, Maastricht, Netherlands, 7Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands

Synopsis

Keywords: Spectroscopy, Spectroscopy, Periaqueductal gray matter (PAG), Ultra-high-field, 1H-MRS in brain

Motivation: Metabolic profiling in periaqueductal gray matter (PAG) is clinically relevant as the PAG is involved in several brain disorders. Considering PAG’s small size, 7T-MRS may be beneficial for reliable metabolic profiling.

Goal(s): To determine the feasibility of in vivo metabolic profiling of the human brainstem PAG at 7T.

Approach: Short-TE 1H-MRS was performed using sLASER sequence at 7T in the PAG of seven young healthy volunteers.

Results: Feasibility of detecting both high and low abundant metabolites in the PAG were demonstrated using 1H-MRS at 7T, which opens new avenues for targeting neurometabolic alterations associated with PAG in several brain disorders.

Impact: This study demonstrates the feasibility of in vivo metabolic profiling of the small, deeply embedded PAG region using 1H-MRS at 7T, which has potential for advancing our understanding of PAG's critical role, in both health and disease.

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Abstract

Keywords