Abstract #2922

In-vivo measurement of taurine with optimized double-quantum-filter technique in human, normal and glioma animal model

Yufan Zhou¹, Yang Cao¹, Xinyi Zhu¹, Ke Zhou¹, Sheng Chen², Chunli Cai³, Jiaqiang Zhou⁴, Feng Chen⁵, Dingyi Lin¹, Yi-Cheng Hsu⁶, and Min Wang^1,4

¹Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China, ³Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China, ⁴Department of Endocrinology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China, ⁵Department of Radiology, School of Medicine, The First Affiliated Hospital, ZhejiangUniversity, Hangzhou, China, ⁶MR Collaboration, Siemens Healthcare Ltd, Shanghai, China

Synopsis

Keywords: Spectroscopy, Brain, Taurine

Motivation: Taurine in the brain plays an important role in neuroprotection, nervous system development and aging mechanisms.

Goal(s): This study aimed to optimize the double-quantum-filter (DQF) MRS technique for the detection of taurine to make the results more reliable and to further enable the in-vivo measurement of taurine.

Approach: Phantom experiments were used to optimize the sequence. Then taurine was measured in animal brains at 7T and in human brains at 3T.

Results: The results measured with the optimized DQF sequence were in better agreement to the true value and provides more reliable quantification compared with direct measurement MRS methods.

Impact: This study optimized the taurine detection technique, and provided a more reliable method for in-vivo measurement of taurine at low field strengths, which provides a non-invasive tool for clinical research of neuromodulation.

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