Keywords: Spectroscopy, Spectroscopy, fMRS, 1H MRS
Motivation: The neurobiological mechanisms underlying poor weight loss maintenance are poorly understood.
Goal(s): Our goal was to study differences in glutamate modulation across different inhibitory motor control task conditions following completion of a clinical weight loss intervention.
Approach: 1H fMRS was conducted on participants following a clinical weight loss intervention.
Results: The use of food cues as stimuli influenced glutamate modulation during inhibitory control and correlated with long-term BMI.
Impact: With further research, this evidence of food-cue specific differences in glutamate modulation predicting long-term BMI may fuel better behavioral treatment plans to support more successful long-term weight loss maintenance in individuals with obesity.
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