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Abstract #2931

Phosphocreatine recovery kinetics as a biomarker to assess therapies targeting mitochondrial function

Manoj K Sammi1, Jonathan Purnell2, Caroline Butler1, Eric Baetscher1, Katherine Powers1, Jarrad Mock3, Supurna Ghosh3, Andreas Kalmes3, and William D. Rooney1
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States, 3Revalesio, Tacoma, WA, United States

Synopsis

Keywords: Other Interventional, Metabolism, Mitochondria, MRS, High Field, Phosphate

Motivation: Skeletal muscle phosphocreatine (PCr) recovery rate constant (kPCr) is a measure of oxidative metabolism under mild exercise conditions.

Goal(s): To test whether kPCr can be used as a biomarker for therapies targeting mitochondrial function.

Approach: kPCr is measured after an isometric exercise in the tibialis anterior muscle of healthy volunteers at 7T with a dual-tuned RF surface coil. RNS60 - an electrokinetically processed saline saturated with oxygen - or placebo were given as an inhalant or by intravenous injection along with baseline experiments to assess changes in mitochondrial metabolism.

Results: kPCr was increased on average by 19% after both RNS60 inhalation and IV injection administration.

Impact: The acute effect on mitochondrial function by RNS60 requires further studies to investigate possible mechanisms of action. kPCr, a non-invasive and quantitative measure, can be applied as a biomarker in other therapies targeting mitochondrial function.

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Keywords