Keywords: Other Interventional, Metabolism, Mitochondria, MRS, High Field, Phosphate
Motivation: Skeletal muscle phosphocreatine (PCr) recovery rate constant (kPCr) is a measure of oxidative metabolism under mild exercise conditions.
Goal(s): To test whether kPCr can be used as a biomarker for therapies targeting mitochondrial function.
Approach: kPCr is measured after an isometric exercise in the tibialis anterior muscle of healthy volunteers at 7T with a dual-tuned RF surface coil. RNS60 - an electrokinetically processed saline saturated with oxygen - or placebo were given as an inhalant or by intravenous injection along with baseline experiments to assess changes in mitochondrial metabolism.
Results: kPCr was increased on average by 19% after both RNS60 inhalation and IV injection administration.
Impact: The acute effect on mitochondrial function by RNS60 requires further studies to investigate possible mechanisms of action. kPCr, a non-invasive and quantitative measure, can be applied as a biomarker in other therapies targeting mitochondrial function.
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