Keywords: Spectroscopy, Metabolism
Motivation: Knowledge of phosphorylated metabolite T1 relaxation times is needed for optimal pulse sequence parameterization, magnetization transfer experiments and for partial T1 saturation correction during quantification.
Goal(s): To measure metabolite relaxation times in the macaque brain at 11.7T without muscle signal contamination.
Approach: Perform inversion-recovery acquisitions with semi-LASER and short-TE STEAM sequences.
Results: T1 relaxation times between 2.6 to 3.0 s were found for phosphodiesters and Pi, ~2.4 s for PCr, 3.6 s for PE, while the T1 values for the ATP-γ and ATP-α resonances were within the 0.8 to 1.0 s range.
Impact: Knowledge of the T1 relaxation times will play a key role in 31P metabolite quantification and in determining the optimal acquisition parameters for 31P MRSI measurements in the macaque brain at 11.7T.
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