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Abstract #2936

Phosphorylated metabolite T1 relaxation times measured in the macaque brain using 31P MRS at 11.7T

Alfredo Liubomir Lopez Kolkovsky1, Marion Gay1, Maxime Roustan1, Thomas Lilin Froment1, Alexis Amadon1, Franck Mauconduit1, and Fawzi Boumezbeur1
1NeuroSpin, CEA, Gif-sur-Yvette, France

Synopsis

Keywords: Spectroscopy, Metabolism

Motivation: Knowledge of phosphorylated metabolite T1 relaxation times is needed for optimal pulse sequence parameterization, magnetization transfer experiments and for partial T1 saturation correction during quantification.

Goal(s): To measure metabolite relaxation times in the macaque brain at 11.7T without muscle signal contamination.

Approach: Perform inversion-recovery acquisitions with semi-LASER and short-TE STEAM sequences.

Results: T1 relaxation times between 2.6 to 3.0 s were found for phosphodiesters and Pi, ~2.4 s for PCr, 3.6 s for PE, while the T1 values for the ATP-γ and ATP-α resonances were within the 0.8 to 1.0 s range.

Impact: Knowledge of the T1 relaxation times will play a key role in 31P metabolite quantification and in determining the optimal acquisition parameters for 31P MRSI measurements in the macaque brain at 11.7T.

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Keywords