Meeting Banner
Abstract #2939

Investigation of exercise-induced skeletal muscle energy metabolism in patients with cirrhosis using dynamic 31P-MRS on a clinical MRI system

Jihun Kwon1, Kumi Ozaki2, Yasutomo Katsumata3, Satoshi Funayama2, Shintaro Ichikawa2, Marc Van Cauteren1, and Satoshi Goshima2
1Philips Japan, Tokyo, Japan, 2Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan, 3Philips Healthcare, Best, Netherlands

Synopsis

Keywords: Spectroscopy, Non-Proton, 31P MRS, liver, cirrhosis

Motivation: As liver function declines, energy stores in the liver is compensated by muscle, resulting in muscle mass loss and, ultimately, sarcopenia. 31P-MRS derived metabolic parameters may allow deeper understanding of muscle energy metabolism in patients with cirrhosis.

Goal(s): Our goal was to compare exercise-induced skeletal muscle energy metabolism between healthy volunteers and cirrhotic patients.

Approach: Dynamic 31P-MRS with exercise challenge was conducted in regular clinical setting and metabolic parameters were evaluated.

Results: Patients with higher Child-Pugh score showed higher Pi/PCr ratio, which may suggest impaired energy metabolism in the muscles of cirrhotic patients prior to the onset of sarcopenia.

Impact: Metabolic parameters derived from dynamic 31P−MRS in clinical setting showed a different trend in patients with cirrhosis compared to those of healthy volunteers. It may be possible to early identify cirrhotic patients at risk of developing sarcopenia.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords