Abstract #2951

Orientation Dependence of MRF-Derived qMRI Parameters in Human Articular Cartilage

Ville Kantola¹, Victor Casula¹, Marvin Werner¹, Martin Englund², Martijn A Cloos³, Riccardo Lattanzi^4,5, Simo Saarakkala^1,6,7, Mikko J Nissi⁸, and Miika Nieminen^1,6,7

¹Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland, ²Faculty of Medicine, University of Lund, Lund, Sweden, ³Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands, ⁴Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ⁵Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ⁶Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, ⁷Medical Research Center, University of Oulu, Oulu, Finland, ⁸Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

Synopsis

Keywords: Cartilage, Cartilage

Motivation: To study the orientation dependence of MRF-derived qMRI parameters in human articular cartilage at clinical field strength.

Goal(s): Measure and compare the orientation dependencies of T1 and T2 relaxation times determined with conventional and MRF sequences on a clinical 3 T MRI scanner.

Approach: Human cartilage samples (N=96) were imaged using conventional qMRI sequences and MRF at two orientations with respect to the main magnetic field.

Results: Both the conventional method and MRF yielded similar T2 values in cartilage along with notable orientation dependencies of similar strength. T1 values were similar between the conventional method and MRF and showed no notable orientation dependence.

Impact: Improving the reliability of parametric mapping using MRF can lead to a significant scan time reduction, improving the throughput of examination in a clinical setting.

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