Keywords: Joint, Perfusion
Motivation: Demonstrate feasibility and efficacy of MRI-targeted embolization therapy for treatment of chronic hip pain due to mild-moderate osteoarthritis.
Goal(s): Determine whether hip embolization therapy can be targeted using DCE-MRI arteriograms. Assess whether quantitative/semi-quantitative perfusion parameters can serve as biomarkers of treatment response.
Approach: Six patients underwent add-on DCE-MR exams after diagnostic hip MRI. Five were eligible for embolization, and two underwent embolization therapy. Baseline perfusion parameters were correlated with HOOS survey scores, and changes to parameters post-embolization were evaluated.
Results: Perfusion parameters correlate with hip pain/function scores both at baseline and after embolization; and may serve as biomarkers of baseline symptom severity/treatment response.
Impact: Chronic hip pain commonly results from osteoarthritis and has few available treatments with demonstrated efficacy. Embolization is a novel therapy for chronic hip pain that has the potential to improve quality-of-life and delay/prevent end-stage arthritis treatments such as total-hip arthroplasty.
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