Abstract #2984

Iron Deposition Versus Demyelination: Chi-Separation Insights into Increased Magnetic Susceptibility in ALS Motor Cortex

Simi Zhou¹, Hiroyuki Kameda^2,3,4, Yoshitaka Bito^1,4, Naoya Kinota^1,2, Daisuke Kato^1,2, Takaaki Fujii^1,2, Xiawei Bai¹, Sooyeon Ji⁵, Kyeongseon Min⁵, Jongho Lee⁵, and Kohsuke Kudo^1,2

¹Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ³Department of Dental Radiology, Hokkaido University Hospital, Sapporo, Japan, ⁴Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan, ⁵Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Synopsis

Keywords: Other Neurodegeneration, Quantitative Imaging, Amyotrophic Lateral Sclerosis (ALS); Chi-separation; χ-separation

Motivation: The role of iron deposition and demyelination in amyotrophic lateral sclerosis (ALS) remains poorly understood. Investigating these factors can provide crucial insights into disease mechanisms.

Goal(s): To elucidate the contributions of iron deposition versus demyelination to increased magnetic susceptibility (χ) observed in the ALS motor cortex using Chi-separation.

Approach: Applied Chi-separation to five patients, generating Chi-paramagnetic, Chi-diamagnetic, and Chi-total maps to differentiate the iron deposition from myelin content.

Results: Chi-separation confirmed the elevated χ values on Chi-para while stable χ values on Chi-dia particularly in the precentral gyrus compared to the postcentral gyrus, indicating iron deposition and less myelin changes.

Impact: This research clarifies the underlying mechanism driving changes in χ values in ALS using Chi-separation, emphasizing the predominant role of iron deposition over demyelination. Such insight highlights its potential for better understanding and potentially monitoring ALS progression.

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