Abstract #2987

Microstructural changes in striatal subregions in sporadic ALS: links to Motor and cognitive deficits and serum biomarkers

Yan Yun¹, Shuangwu Liu², Jiaxiang Xin³, Yunyu Wang¹, Yi Wu¹, Tong Shen¹, Mengyuan Zhuo⁴, and Dexin Yu¹

¹Radiology, Qilu Hospital of Shandong University, Jinan, China, ²School of Nursing and Rehabilitation, Shandong University, Jinan, China, ³MR Collaboration, Siemens Healthineers Ltd., Jinan, China, ⁴Radiology, Shandong Provincial Hospital, Shandong University, Jinan, China

Synopsis

Keywords: Other Neurodegeneration, Gray Matter

Motivation: Striatal changes in patients with amyotrophic lateral sclerosis (ALS), including neurodegeneration and disrupted connectivity, lead to motor and cognitive-behavioral deficits.

Goal(s): Revealing microstructural damage in the striatal subregions of ALS patients.

Approach: NODDI diffusion technique was employed to analyze striatal subregions in 79 ALS patients and 53 healthy controls, correlating the imaging findings with clinical assessments and serum NfL levels.

Results: The NDI of the left motor striatal subregion was significantly linked to ALSFRS-R scores and serum NfL levels.

Impact: The study revealed notable microstructural changes in the striatum of ALS patients, emphasizing the potential of NODDI as a neuroimaging marker.

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