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Abstract #2988

Early extra-motor brain iron accumulation is linked to cognitive deficits in sporadic early-stage amyotrophic lateral sclerosis patients

Yan Yun1, Shuangwu Liu2, Dmytro Pylypenko3, Tong Shen1, Yi Wu1, Yunyu Wang1, Runcheng Zeng4, and Dexin Yu1
1Radiology, Qilu Hospital, Shandong University, Jinan, China, 2School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China, 3GE Healthcare, MR Research China, Beijing, China, 4Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, China

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration

Motivation: Understanding iron metabolism abnormalities in early-stage ALS is essential for revealing the disease’s multisystemic effects and link to cognitive deficits.

Goal(s): This study aims to identify brain iron accumulation patterns through quantitative susceptibility mapping (QSM) and assess their connection to cognitive impairments in newly diagnosed sporadic ALS patients.

Approach: We performed voxel-based whole-brain QSM analysis in 53 early-stage ALS patients and 50 healthy controls, correlating iron deposition patterns with clinical assessments and cognitive scores.

Results: Significant iron accumulation in motor and extra-motor regions of ALS patients correlates with cognitive deficits, highlighting QSM’s potential for early neuroanatomical detection in ALS.

Impact: This study identifies widespread brain iron accumulation as a hallmark of early-stage ALS, linked to cognitive decline. Findings highlight QSM’s potential as an early diagnostic tool and suggest iron metabolism as a promising therapeutic target.

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