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Abstract #2989

Choroid Plexus Volume and Susceptibility in Spinocerebellar Ataxia Type 3

Bing Liu1, Linwei Zhang2, Xi Li1, Fuxin Ren1, and Fei Gao1
1Department of radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Department of neurology, China Japan Friendship Hospital, Beijing, China

Synopsis

Keywords: Other Neurodegeneration, Quantitative Susceptibility mapping, choroid plexus

Motivation: The relationship between choroid plexus (CP) imaging profile in SCA3 and its clinical ataxia severity remains unclear.

Goal(s): To evaluate CP volume, and CP susceptibility changes between SCA3 patients and healthy controls, and their clinical relevance in vivo.

Approach: A deep learning based CP auto-segmentation method was used to generate CP mask. CP volume and susceptibility were then extracted by overlaying the mask on T1 and QSM images.

Results: CP volume was greater in SCA3 patients, and was significantly associated with clinical ataxia severity.
CP susceptibility was negatively associated with its volume in both patients and healthy controls.

Impact: CP volume may be a novel neuroimaging marker associated with clinical ataxia severity. Assessing CP volume and other image profile may be a noninvasive and easy-to-implement approach for screening disease process in SCA3 patients.

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