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Abstract #2997

Pathological changes in brain networks in P301S tau transgenic mouse model

Hinako Oshiro1,2, Komomo Kawamata1, Junichi Hata1,2,3, Riki Koike4, Takuto Marusaki1, Ayane Ishida1,2, Chino Kawai1, Chika Tokisugi1, Yoshiyuki Soeda4, Akihiko Takashima4, and Hideyuki Okano2,3
1Tokyo Metropolitan University, Tokyo, Japan, 2RIKEN, Center for Brain Science, Saitama, Japan, 3Keio University, Tokyo, Japan, 4Gakushuin University, Tokyo, Japan

Synopsis

Keywords: Alzheimer's Disease, Neuroscience, tauopathy, PS19 transgenic, diffusion, functional, connectivity

Motivation: Visualization of pathological changes in tauopathy is expected to elucidate its detailed clinical symptoms.

Goal(s): Our goal was to assess the pathological changes in a tauopathy mouse model by measuring brain function and structural networks.

Approach: Wild-type and tauopathy mouse models (PS19) aged 3, 6, and 9 months were evaluated using awake functional MRI. After perfusion fixation, ex vivo brain were measured using diffusion MRI.

Results: The PS19 mice exhibited decreased neuronal function in the amygdala, hippocampus, entorhinal and perirhinal cortices. Three-month-old PS19 mice showed a significant decrease in fiber orientation distribution in the entorhinal and perirhinal cortices.

Impact: The establishment of tauopathy imaging using MRI could lead to the early and non-invasive detection of tau-related diseases, such as Alzheimer's disease.

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Keywords