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Abstract #2998

Effect of protein concentration on MRI quantitative values: Comparison between 7T MRI and 11.7T MRI.

Kazuki Tateno1,2, Yuji Komaki2, Koichi Oshio2,3, Nobuhiro Nitta2, and Junichi Hata1
1Department of Radiology, Faculty of Health and Welfare, Tokyo Metropolitan University, Tokyo, Japan, 2Central Institute for Experimental Medicine and Life Science, Tokyo, Japan, 3Juntendo University, Tokyo, Japan

Synopsis

Keywords: Alzheimer's Disease, Brain, protein concentration

Motivation: Studies investigating the brain clearance system using T2 measurements have already begun; however, the dependence of T2 values on protein concentration, which is the basis of this study, is still unknown.

Goal(s): This study aimed to clarify the effect of protein concentration in the solution on each MRI quantitative value.

Approach: Each MRI quantification value was calculated by imaging an albumin phantom with varying protein concentrations, solution temperatures, and magnetic field intensities.

Results: The T2 value was the most sensitive to changes in albumin concentration, suggesting that the T2 value is capable of estimating the solute concentration in the brain.

Impact: The effect of protein concentration on each quantitative MRI value was determined. The results showed that T2 most acutely captured changes in albumin concentration. A more detailed T2 analysis revealed the possibility of estimating solute concentration in the brain.

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