Abstract #3016

In Vivo Vessel Size Imaging Using 9.4 T MRI: Histopathological Validation

dongnan zhao¹, ke zhang², shiji li¹, lifei huang³, chen chen⁴, shuheng zhang⁴, qian wan⁵, and na zhang^6,7

¹Shenzhen Institute of Advanced Technology, shenzhen, China, ²Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany, ³United Imaging Life Science Instrument, shenzhen, China, ⁴Shanghai United Imaging Healthcare, shanghai, China, ⁵Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, shenzhen, China, ⁶United Imaging Research Institute of Innovative Medical Equipment, shenzhen, China, ⁷Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, shenzhen, China

Synopsis

Keywords: Small Animals, Brain

Motivation: Vessel size imaging (VSI) of contrast-agent based MRI can be used to measure the structural and topological heterogeneity of microvascular networks.

Goal(s): The aim of this study is to investigate the feasibility and effectiveness of vessel size imaging on 9.4T MRI

Approach: We implanted C6 gliomas in situ in Wistar rats and quantified VSI at 9.4T MRI. Following staining with the endothelial cell marker CD31, we assessed the correlation between VSI-MRI measurements and vessel radius using immunohistochemistry.

Results: The elevated VSI and CBV values in the tumor region align with the increased vascular proliferation and vessel enlargement observed in histological analysis.

Impact: Comparing VSI-MRI with histopathological validation provides crucial insights into vascular structure in tumors, enhancing non-invasive characterization accuracy. This method could improve tumor diagnosis, monitoring, and treatment planning by reliably correlating imaging results with microscopic vascular architecture.

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