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Abstract #3019

Metabolic Profiling of Serum & Saliva in OSCC: A Combined Biofluid Approach for Enhanced Biomarker Discovery using 1H NMR.

Shivani Tripathi1, Nisha Chauhan1, Sandeep Bhoriwal2, Sadhana Kumari1, Pankaj .1, Ekta Dhamija2, S Senthil Kumaran1, Renugopalakrishnan Venkatesan3, Bansi Malhotra4, and Ramasamy Paulmurugan5
1Nuclear Magnetic Resonance, All India Institute of Medical Sciences, Delhi, India, 2BRA-IRCH, All India Institute of Medical Sciences, Delhi, India, 3Chemistry and Chemical Biology, Northeastern University, Boston, MA, United States, 4Applied Physics, Delhi Technical University, Delhi, India, 5Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Cancer, Head & Neck/ENT, Oral Squamous Cell Carcinoma, 1H NMR, Biomarker

Motivation: Early detection of oral cancer remains challenging. There’s a critical need for accessible, non-invasive biomarkers that can improve early diagnosis, helping to enhance survival rates and treatment outcomes for Oral Squamous Cell Carcinoma (OSCC) patients.

Goal(s): To identify potential diagnostic biomarkers for OSCC by profiling metabolic changes in serum and saliva.

Approach: Using 1H NMR metabolomics, saliva and serum were analyzed to identify pathway and metabolic alteration in OSCC patients compared to controls.

Results: Elevated methanol and disrupted phenylalanine, tyrosine, and tryptophan pathways were observed in both biofluids, indicating potential OSCC biomarkers. The combined biofluid approach shows promise for non-invasive early OSCC detection.

Impact: This study highlights the potential of using combined serum and saliva metabolomic profiling as a non-invasive approach to identify reliable biomarkers for early OSCC detection, offering a promising tool for improved diagnostic accuracy and timely intervention.

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